Of which motive non-sensory signs and symptoms, together with muscle weak spot or lightheadedness. Diagnosis of Painful Peripheral Neuropathy Nerve Renew Diagnosis of painful peripheral neuropathy may require several steps. A clinical examination will contain taking a complete patient history and checking tendon reflexes, muscle strength, motor feature and the feel of contact. Additionally, urine and blood specimens can be asked to check for metabolic or autoimmune issues. Other assessments is probably wanted.